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Current Opinion in Cell BiologyVolume 4, Issue 3, June 1992, Pages 379-384 Author links open overlay panel https://doi.org/10.1016/0955-0674(92)90002-TGet rights and content AbstractCentromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telomeres perform their various roles in a cell
References (59)
Centromeres of Mammalian ChromosomesTrends Genet(1990) Structure and Function of TelomeresAnnu Rev Genet(1989) Structure and Function of TelomeresNature(1991) Telomeres Inhibit End to End Fusion and Enhance Maintenance of Linear DNA Molecules Injected into the Paramecium primaurelia MacronucleusNucleic Acids Res(1991) When is a Centromere not a Kinetochore?J Cell Sci(1991) In Vivo Genomic Footprint of a Yeast CentromereMol Cell Biol(1991) CPFI, a Yeast Protein which Functions in Centromeres and PromotersEMBO J(1990) In Vivo Characterization of the Saccharomyces cerevisiae Centromere DNA Element 1, a Binding Site for the Helix-Loop-Helix Protein CPFIMol Cell Biol(1991) DNA-binding of CPFI is Required for Optimal Centromere Function but not for Maintaining Methionine Prototropy in YeastNucleic Acids Res(1991) Suppressor of a Centromere DNA Mutation Encodes a Putative Protein Kinase (MCK1)Genes Dev(1991) Centromere-dependent Binding of Yeast Minichromosomes to Microtubules in VitroCell(1991) Composite Motifs and Repeat Symmetry in S. Pombe Centromeres: Direct Anal ysis by Integration of Nod Restriction SitesCell(1989) Clustered tRNA Genes in Schizosaccharomyces pombe Centromeric DNA Sequence RepeatsFunctional Analysis of a Centromere from Fission Yeast: a Role for Centromere-specific Repeated DNA sequencesMol Cell Biol(1990) The Chromatin Structure of Centromeres from Fission Yeast: Differentiation of the Central Core that Correlates with FunctionJ Cell Biol(1991) Physical Map of the Centromeric Region of Human Chromosome 7: Relationship between Two Distinct Alpha Satellite ArraysNucleic Acids Res(1991) Characterization of a Short, Highly Repeated and Centromerically Localized DNA Sequence in Crested and Marbled Newts of the Genus triturusChromosoma(1990) Partial Deletion of Alpha Satellite DNA Associated with Reduced Amounts of the Centromere Protein CENP-B in a Mitotically Stable Human Chromosome RearrangementMol Cell Biol(1990) The Centromere-Kinetochore Complex: a Repeat Subunit ModelJ Cell Biol(1991) Cited by (17)
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Copyright © 1992 Published by Elsevier Ltd. What is heterochromatin formation?Heterochromatin formation is initiated at silencers that are composed of binding sites for sequence-specific DNA-binding proteins. These DNA-binding proteins (together with Sir1 at the mating type loci) recruit the Sir complex, which then spreads across the entire locus.
What are telomeres quizlet?A telomere is a region of. repetitive nucleotide sequences at each end of a chromosome. Telomere shortening occurs on the. Lagging strand of DNA during DNA replication.
What is a telomere simple definition?(TEH-loh-meer) The ends of a chromosome. Each time a cell divides, the telomeres lose a small amount of DNA and become shorter. Over time, the chromosomes become damaged and the cells die. In cancer cells the telomeres do not get shorter, and may become longer, as the cells divide.
Why does DNA form heterochromatin?Heterochromatin has been associated with several functions, from gene regulation to the protection of chromosome integrity; some of these roles can be attributed to the dense packing of DNA, which makes it less accessible to protein factors that usually bind DNA or its associated factors.
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