General High Alert Medication: This medication bears a heightened risk of causing significant patient harm when it is used in error. Genetic Implications: Pronunciation:
Trade Name(s) Ther.
Class. anticoagulants Pharm. Class. coumarins Indications
Action Interferes with hepatic synthesis of vitamin K-dependent clotting factors (II, VII, IX, and X). Therapeutic Effect(s): Prevention of thromboembolic events. PharmacokineticsAbsorption: Well absorbed from the GI tract after oral administration. Distribution: Crosses the placenta but does not enter breast milk. Protein Binding: 99%. Metabolism and Excretion: Primarily metabolized by the liver via the CYP2C9 isoenzyme, with some metabolism via the CYP3A4 isoenzyme; the CYP2C9 isoenzyme exhibits genetic polymorphism (intermediate or poor metabolizers may have significantly ↑ (S)-warfarin concentrations and an ↑ risk of adverse reactions).. Half-life: 42 hr. TIME/ACTION PROFILE (effects on coagulation tests)
Contraindication/PrecautionsContraindicated in:
Use Cautiously in:
Adverse Reactions/Side EffectsDerm: dermal necrosis GI: cramps, nausea GU: CALCIPHYLAXIS Hemat: BLEEDING Misc: fever * CAPITALS indicate life-threatening. InteractionsDrug-Drug
Drug-Natural Products:
Drug-Food: Ingestion of large quantities of foods high in vitamin K content (see list in food sources for specific nutrients) may antagonize the anticoagulant effect of warfarin. Route/DosagePO (Adults): 2–5 mg/day for 2–4 days; then adjust daily dose by results of INR. Initiate therapy with lower doses in geriatric or debilitated patients or in Asian patients or those with CYP2C9*2 and/or CYP2C9*3 alleles or VKORC1 AA genotype. PO (Children >1 mo): Initial loading dose– 0.2 mg/kg (maximum dose: 10 mg) for 2–4 days then adjust daily dose by results of INR, use 0.1 mg/kg if liver dysfunction is present. Maintenance dose range– 0.05–0.34 mg/kg/day. Availability (generic available)Tablets: 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, 10 mg Cost: Generic: 1 mg $10.83/100, 2 mg $10.83/100, 2.5 mg $10.83/100, 3 mg $10.83/100, 4 mg $10.83/100, 5 mg $8.52/100, 6 mg $10.64/100, 7.5 mg $10.83/100, 10 mg $10.83/100 Assessment (adsbygoogle = window.adsbygoogle || []).push({});
Lab Test Considerations: Monitor PT, INR and other clotting factors frequently during therapy; monitor more frequently in patients with renal impairment. Therapeutic PT ranges 1.3–1.5 times greater than control; however, the INR, a standardized system that provides a common basis for communicating and interpreting PT results, is usually referenced. Normal INR (not on anticoagulants) is 0.8–1.2. An INR of 2.5–3.5 is recommended for patients at very high risk of embolization (for example, patients with mitral valve replacement and ventricular hypertrophy). Lower levels are acceptable when risk is lower. Heparin may affect the PT/INR; draw blood for PT/INR in patients receiving both heparin and warfarin at least 5 hr after the IV bolus dose, 4 hr after cessation of IV infusion, or 24 hr after subcut heparin injection. Asian patients and those who carry the CYP2C9*2 allele and/or the CYP2C9*3 allele, or those with VKORC1 AA genotype may require more frequent monitoring and lower doses.
Toxicity and Overdose: Withholding 1 or more doses of warfarin is usually sufficient if INR is excessively elevated or if minor bleeding occurs. If overdose occurs or anticoagulation needs to be immediately reversed, the antidote is vitamin K (phytonadione, Aquamephyton). Administration of whole blood or plasma also may be required in severe bleeding because of the delayed onset of vitamin K. Implementation
Patient/Family Teaching
Evaluation/Desired OutcomesProlonged PT (1.3–2.0 times the control; may vary with indication) or INR of 2–4.5 without signs of hemorrhage. warfarin is a sample topic from the Davis's Drug Guide. To view other topics, please log in or purchase a subscription. Nursing Central is an award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Complete Product Information. What is the route of administration for warfarin?Warfarin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take warfarin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Is warfarin administered IV?Warfarin for injection should be administered as a slow bolus over 1–2 minutes into a peripheral vein. 6 It is not to be given intramuscularly and is not approved for direct intravenous push.
Why is warfarin administered?WHY DO I NEED WARFARIN? Warfarin is prescribed for people who are at increased risk for developing harmful blood clots. This includes people with a mechanical heart valve, an irregular heart rhythm called atrial fibrillation, certain clotting disorders, or a higher risk of a clot after hip or knee surgery.
Which drug should be used in maintaining warfarin therapy?Vitamin K1 can be given orally or intravenously to reverse the effect of warfarin in patients with INRs above 10 or those with bleeding or a high risk of bleeding. In patients who are not actively bleeding, it is important to avoid overtreatment as this will make it difficult to re-establish control of the INR.
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